Smoking and insulin resistance

Smoking and insulin resistance

Smoking and insulin resistance: Data from 4043 participants sourced from the Korea National Health and Nutrition Examination Survey, conducted from 2016 to 2018, were examined. Short-term smoking patterns were wont to classify participants consistent with urine levels of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and cotinine as continuous-smokers, past-smokers, current-smokers, and non-smokers. Insulin resistance was calculated using the triglyceride-glucose index from blood samples and was defined as either high or low.

Smoking and insulin resistance

Multiple logistic multivariate analysis was performed to research the association between smoking behavior and insulin resistance(Diabetes). Men and ladies who were continuous-smokers (men: odds ratio [OR] = 1.74, p = 0.001; women: OR = 2.01, p = 0.001) and past-smokers (men: OR = 1.47, p = 0.033; women: OR = 1.37, p = 0.050) were more likely to possess high insulin resistance than their non-smoking counterparts. Long-term smokers (≥ 40 days) are at an increased risk of insulin resistance in short-term smoking patterns. Smoking cessation may protect against insulin resistance.

Insulin resistance may be a growing disorder worldwide and is related to a number of the foremost common diseases affecting the fashionable society, including diabetes, high vital sign , obesity, and coronary heart disease. Direct methods of assessing insulin resistance include euglycemic-hyperinsulinemia clamp and insulin suppression tests and straightforward indirect indicators are estimated by the homeostasis model assessment of insulin resistance (HOMA-IR).

Recently, the triglyceride and glucose (TyG) index, an easy and accurate marker of insulin resistance, has been proposed, which uses fasting triglyceride and blood sugar levels for calculation6. The TyG index can help screen people at high risk of DM with an easy biopsy . Furthermore, studies using the TyG index in adults within the Republic of Korea showed that a rise within the TyG index was related to a rise within the prevalence of arteria coronaria.


Smoking may be a lifestyle factor which will directly or indirectly affect insulin resistance9. Several prospective studies on the connection between smoking and insulin resistance have shown that smoking may be a risk factor for insulin resistance. However, these studies have mostly used self-reporting as a way of measuring exposure to smoking, and this might have led to incorrect measurement, as self-reported and biomarker results show a consistency of only 46–53%; additionally , self-reports tend to be unreliable for quantitative assessments of smoking volume14,15. These findings suggest that an objective method of measuring smoking volume is required to account for the inherent bias in self-reported data.

Cotinine is that the main metabolite of nicotine present within the blood, urine, hair, and saliva and is taken into account an indicator of exposure to nicotine smoke or current smoking. While nicotine features a half-life of around 2 h within the blood, cotinine features a half-life of 18–24 h and reflects the accumulated exposure to environmental tobacco smoke. especially, urine cotinine levels may help determine the contribution of smoke within the air during the sampling process to the entire smoking exposure within Diabetes.

4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNAL) has been used extensively to assess the accuracy of self-reported smoking status. NNAL is widely referred to as a biomarker of nicotine-derived nitrosamine ketone, a tobacco-specific lung carcinogen. Furthermore, NNAL, thanks to its half-life of roughly 40 days, is beneficial for its tobacco specificity, association with carcinogen intake, facilitation of consistent detection of individuals exposed to tobacco, and evaluation of long-term exposure to harmful substances.

Demographic characteristics:

Of 4,043 participants, 2,067 (51.1%) were males (Table 1). Of the 2,067 male participants, 839 (40.6%), 454 (22.0%), 12 (0.6%), and 762 (36.9%) were continuous-smokers, past-smokers, current-smokers, and non-smokers, respectively. Of the 1976 (48.9%) female participants, 201 (10.2%), 452 (22.9%), 22 (1.1%), and 1301 (65.8%) were continuous-smokers, past-smokers, current-smokers, and non-smokers, respectively.

The insulin resistance groups differed with reference to all factors except educational levels, household income, region, occupational categories, energy intake levels, secondhand smoking exposure, and therefore the survey year.

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